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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:61668
Term: oroxylin A
Definition: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6.
Chemical ID: MESH:C080669
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTD5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 proteinPMID:30790579
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTD5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNAPMID:23470866
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein; diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA]PMID:23470866 PMID:30790579
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