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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of ABCB1A mRNAPMID:15834898 PMID:17351261
Abcb1aaffects expressionISOAbcb1a (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of ABCB1A mRNAPMID:17555576
Abcb1adecreases expressionISOAbcb1a (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of ABCB1A mRNAPMID:17942748
Abcb1aincreases exportISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased export of Ethinyl EstradiolPMID:15290871
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDEthinyl Estradiol results in increased expression of ABCB1 mRNA; Ethinyl Estradiol results in increased expression of ABCB1 proteinPMID:15290871 PMID:24685904
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB1A mRNAPMID:17942748
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDElacridar results in decreased export of [ABCB1 protein results in increased transport of Ethinyl Estradiol]; Ethinyl Estradiol results in increased expression of and results in increased activity of ABCB1 protein; Fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCB1 protein]PMID:15290871 PMID:24685904
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