A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID:
MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[Cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol; [Thioacetamide co-treated with Cyclosporine] results in increased expression of ABCB1 mRNA; Cyclosporine inhibits the reaction [ABCB1 results in decreased susceptibility to Cadmium Chloride]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Paliperidone Palmitate]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]
ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Cyclosporine]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
[Cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of Digoxin; [Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 mRNA; [Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 protein; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylhypaconine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of mesaconitine; [Cyclosporine results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; Cyclosporine binds to and results in decreased activity of ABCB1 protein; Cyclosporine inhibits the reaction [ABCB1 protein affects the export of calcein AM]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]; Cyclosporine inhibits the reaction [ABCB1 protein results in decreased uptake of Doxorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of globotriaosylceramide]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Glucosylceramides]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased chemical synthesis of Lactosylceramides]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Diazinon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of Fluorescent Dyes]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]; Cyclosporine inhibits the reaction [ABCB1 protein results in increased secretion of Vinblastine]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Daunorubicin]; Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Technetium Tc 99m Sestamibi]; Cyclosporine inhibits the reaction [Verapamil analog results in increased activity of ABCB1 protein mutant form]; Plant Extracts affects the reaction [ABCB1 protein results in increased transport of Cyclosporine]
