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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects localizationEXP 6480464CTDLipopolysaccharides affects the localization of ABCB1 proteinPMID:28842383
Abcb1adecreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of ABCB1 mRNA; Lipopolysaccharides results in decreased expression of ABCB1A mRNAPMID:15205389 PMID:28842383
Abcb1amultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCB1A mRNA]; GCG protein inhibits the reaction [Lipopolysaccharides affects the localization of ABCB1 protein]; GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCB1 mRNA]; GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of ABCB1 protein]; Lipopolysaccharides results in decreased expression of and results in decreased activity of ABCB1 proteinPMID:15205389 PMID:28842383
Abcb1aaffects expressionISOAbcb1a (Mus musculus)6480464CTDLipopolysaccharides affects the expression of ABCB1A proteinPMID:15778272
Abcb1adecreases activityISOAbcb1a (Mus musculus)6480464CTDLipopolysaccharides results in decreased activity of ABCB1A proteinPMID:14709616 PMID:23762418
Abcb1adecreases expressionISOAbcb1a (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of ABCB1A mRNAPMID:14709616 PMID:15778272
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDLipopolysaccharides affects the reaction [ABCB1A protein results in increased secretion of Doxorubicin]PMID:15778272
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of ABCB1 mRNAPMID:26667767
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