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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:10033
Term: warfarin
Definition: A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.
Chemical ID: MESH:D014859
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 polymorphism affects the susceptibility to WarfarinPMID:24092646 PMID:25312789
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTDWarfarin results in increased expression of ABCB1A mRNAPMID:27397090
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