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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619871
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
Acc ID: CHEBI:65737
Term: demethoxycurcumin
Definition: A beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior.
Chemical ID: MESH:C050229
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gclmincreases expressionISOGCLM (Homo sapiens)6480464CTDdemethoxycurcumin results in increased expression of GCLM mRNA; demethoxycurcumin results in increased expression of GCLM proteinPMID:19188863 PMID:23386263
Gclmincreases expressionISOGclm (Mus musculus)6480464CTDdemethoxycurcumin results in increased expression of GCLM mRNAPMID:17535857
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