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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fas
Name: Fas cell surface death receptor
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasincreases expressionISOFAS (Homo sapiens)6480464CTDHydroxyurea results in increased expression of FAS mRNAPMID:16005713
Fasincreases expressionISOFas (Mus musculus)6480464CTDHydroxyurea results in increased expression of FAS mRNA; Hydroxyurea results in increased expression of FAS proteinPMID:16356682 PMID:26399158 PMID:27208086 PMID:29228353
Fasmultiple interactionsISOFas (Mus musculus)6480464CTDTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased expression of FAS mRNA]PMID:29228353
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