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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61906
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h2affects localizationISONR1H2 (Homo sapiens)6480464CTDEtoposide affects the localization of NR1H2 proteinPMID:25914138
Nr1h2affects response to substanceISONR1H2 (Homo sapiens)6480464CTDNR1H2 protein affects the susceptibility to EtoposidePMID:25914138
Nr1h2multiple interactionsISONR1H2 (Homo sapiens)6480464CTDEtoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]; NR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]PMID:25914138
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