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GENE - TERM ANNOTATION REPORT

RGD ID: 61890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
Acc ID: GO:0000165
Term: MAPK cascade
Definition: An intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
Definition Source(s): PMID:20811974, PMID:9561267
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k5 ICGO:000646861658RGD  
Map2k5acts_upstream_of_or_withinISOMap2k5 (Mus musculus)1624291RGDMGI:3526901 PMID:15601854

PMID:15601854
Map2k5involved_inIMP 8553940BHF-UCLPMID:20551324

 
Map2k5involved_inIBAFB:FBgn0010269 or FB:FBgn0024326 or FB:FBgn0261524 or MGI:1346345 or MGI:1346866 or MGI:1346867 or MGI:1346868 or MGI:1346869 or MGI:1346870 or MGI:1346871 or PANTHER:PTN000684494 or PomBase:SPAC1D4.13 or PomBase:SPBC409.07c or PomBase:SPBC543.07 or Map2k7 (Rattus norvegicus) or Map2k5 (Rattus norvegicus) or SGD:S000002318 or SGD:S000003664 or SGD:S000005757 or SGD:S000006061 or UniProtKB:O14733 or UniProtKB:P36507 or UniProtKB:P46734 or UniProtKB:P52564 or WB:WBGene00003185 or WB:WBGene00003186 or WB:WBGene00003368 or WB:WBGene000047581600115GO_CentralGO_REF:0000033

GO_REF:0000033
Map2k5involved_inIMP 401901210UniProtPMID:20724525

 
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