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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9affects expressionEXP 6480464CTDCocaine affects the expression of CASP9 proteinPMID:16179556
Casp9increases activityEXP 6480464CTDCocaine results in increased activity of CASP9 proteinPMID:10604926 PMID:11392460 PMID:12639677 PMID:15365088 PMID:16638611 PMID:17084983 PMID:17635674 PMID:18974856
Casp9multiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Cocaine results in increased activity of CASP9 protein]PMID:15365088
Casp9affects expressionISOCasp9 (Mus musculus)6480464CTDCocaine affects the expression of CASP9 mRNAPMID:15681117
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDCocaine results in increased expression of CASP9 proteinPMID:16686379
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