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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61865
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lbp
Name: lipopolysaccharide binding protein
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lbpincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of LBP mRNAPMID:16309824
Lbpaffects bindingISOLBP (Homo sapiens)6480464CTDLipopolysaccharides binds to LBP proteinPMID:19540866 PMID:21261300
Lbpincreases expressionISOLBP (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of LBP proteinPMID:20699433
Lbpincreases expressionISOLbp (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of LBP mRNAPMID:27339419
Lbpincreases response to substanceISOLBP (Homo sapiens)6480464CTDLBP polymorphism results in increased susceptibility to LipopolysaccharidesPMID:22167001
Lbpmultiple interactionsISOLBP (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of LBP mRNA; Ketamine inhibits the reaction [Lipopolysaccharides binds to LBP protein]PMID:19540866 PMID:35811015
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