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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:9986
Term: vinclozolin
Definition: A racemate comprising equimolar amounts of (R)- and (S)-vinclozolin. A fungicide used mainly on oilseed rape, vines, fruit and vegetables to control Botrytis, Sclerotinia and Monilia spp.
Chemical ID: MESH:C025643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTD[Genistein co-treated with vinclozolin] results in decreased expression of TP53 mRNAPMID:32827888
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDvinclozolin results in decreased expression of TP53 proteinPMID:36498866
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDvinclozolin results in increased expression of TRP53 mRNAPMID:18940246
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