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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:58987
Term: sildenafil citrate
Definition: The citrate salt of sildenafil.
Chemical ID: MESH:D000068677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDSildenafil Citrate results in increased expression of TP53 proteinPMID:38059649
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDTP53 protein inhibits the reaction [Sildenafil Citrate results in increased susceptibility to Doxorubicin]PMID:20155316
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