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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:27086
Term: tributylstannane
Definition: An organotin compound that has formula C12H28Sn.
Chemical ID: MESH:C011559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDtributyltin results in decreased expression of TP53 proteinPMID:26961604
Tp53increases expressionISOTrp53 (Mus musculus)6480464CTDtributyltin results in increased expression of TRP53 proteinPMID:33720505 PMID:36319700
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDtributyltin results in increased expression of TP53 proteinPMID:25743928 PMID:36319700
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased expression of TP53 protein]; pyrazolanthrone inhibits the reaction [tributyltin results in increased expression of TP53 protein]PMID:36319700
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