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GENE - TERM ANNOTATION REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: GO:0097527
Term: necroptotic signaling pathway
Definition: The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.
Definition Source(s): GOC:mtg_apoptosis, PMID:20823910
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfacts_upstream_of_or_withinISOTnf (Mus musculus)1624291RGDMGI:108212 MGI:1197009 MGI:1261423 MGI:1336166 MGI:1346877 MGI:1921506 MGI:2154952 PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414

PMID:19498109 PMID:21052097 PMID:21368763 PMID:22037414
Tnfinvolved_inISOTNF (Homo sapiens)1624291RGD PMID:11101870 PMID:22265413 PMID:22265414 PMID:22817896

PMID:11101870 PMID:22265413 PMID:22265414 PMID:22817896
Tnfinvolved_inIEAUniRule:UR0015917841600115UniProtGO_REF:0000104

GO_REF:0000104
Tnfinvolved_inISSUniProtKB:P013751600115UniProtGO_REF:0000024

GO_REF:0000024
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