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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:8378
Term: prednisolone
Definition: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Chemical ID: MESH:D011239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfdecreases expression ISOTNF (Homo sapiens)40903016RGDprednisolone decreases expression of TNFa mRNA and protein in LPS-stimulated human PBMC 
Tnfdecreases expressionEXP 6480464CTDPrednisolone results in decreased expression of TNF mRNAPMID:11043609
Tnfmultiple interactionsEXP 6480464CTD[pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Amiodarone results in increased expression of TNF protein]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]PMID:22119283 PMID:28921394 PMID:34590760
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDPrednisolone results in increased expression of TNF mRNAPMID:19233868
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDPrednisolone inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]PMID:20054000
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDPrednisolone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]PMID:36416909
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