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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:76359
Term: butylated hydroxyanisole
Definition: A mixture of 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. Is is used as an antioxidant and preservative in food, cosmetics, pharmaceuticals, rubber and petroleum products.
Chemical ID: MESH:D002083
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTD[Food Preservatives results in increased abundance of Butylated Hydroxyanisole] which results in increased expression of TNF mRNAPMID:32179172
Tnfaffects response to substanceISOTNF (Homo sapiens)6480464CTDButylated Hydroxyanisole affects the susceptibility to TNF proteinPMID:8740460
Tnfdecreases response to substanceISOTnf (Mus musculus)6480464CTDButylated Hydroxyanisole results in decreased susceptibility to TNF proteinPMID:10588948
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDButylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]; Butylated Hydroxyanisole inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]; DUSP1 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; NFE2L2 protein affects the reaction [Butylated Hydroxyanisole affects the reaction [Dextran Sulfate affects the expression of TNF protein]]; TNFRSF1A protein affects the reaction [Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Arachidonic Acid]]PMID:10588948 PMID:30844440 PMID:8186192
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDButylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of ATP6V1A protein]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of COX2 protein]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in decreased expression of PSMC6 mRNA]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased abundance of Dinoprostone]; Butylated Hydroxyanisole inhibits the reaction [TNF protein results in increased secretion of Arachidonic Acid]PMID:12470298 PMID:1515551
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