Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3876
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tnf
Name:	tumor necrosis factor

Acc ID:	CHEBI:7549
Term:	N(gamma)-nitro-L-arginine methyl ester
Definition:	An alpha-amino acid ester that is the methyl ester of N(gamma)-nitro-L-arginine.
Chemical ID:	MESH:D019331

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnf	increases expression	EXP		6480464	CTD	NG-Nitroarginine Methyl Ester results in increased expression of TNF mRNA; NG-Nitroarginine Methyl Ester results in increased expression of TNF protein	PMID:32172062 PMID:32428650 PMID:32810514 PMID:37718616 PMID:38029875
Tnf	multiple interactions	EXP		6480464	CTD	[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA; [Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]]; alpha-Linolenic Acid inhibits the reaction [Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF mRNA]; bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; NG-Nitroarginine Methyl Ester inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Particulate Matter inhibits the reaction [alpha-Linolenic Acid inhibits the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF mRNA]; Particulate Matter promotes the reaction [[Cholesterol, Dietary co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]	PMID:29423081 PMID:30529211 PMID:32172062 PMID:32428650 PMID:32810514 PMID:37718616 PMID:38029875
Tnf	multiple interactions	ISO	Tnf (Mus musculus)	6480464	CTD	[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA]	PMID:38705399
Tnf	multiple interactions	ISO	TNF (Homo sapiens)	6480464	CTD	[NG-Nitroarginine Methyl Ester co-treated with TNF protein] results in increased secretion of VWF protein	PMID:34678311

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