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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:72959
Term: N-hexadecanoylsphingosine
Definition: A N-acylsphingosine in which the ceramide N-acyl group is specified as hexadecanoyl (palmitoyl).
Chemical ID: MESH:C097760
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases abundanceISOTnf (Mus musculus)6480464CTDTNF protein results in increased abundance of N-palmitoylsphingosinePMID:15946935
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDImipramine inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]PMID:15946935
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDASAH2 protein inhibits the reaction [TNF protein results in increased abundance of N-palmitoylsphingosine]PMID:15946935
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