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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:69120
Term: withaferin A
Definition: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Physalis longifolia, it exhibits cytotoxic activity.
Chemical ID: MESH:C009684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDwithaferin A inhibits the reaction [Cholesterol, Dietary results in increased expression of TNF protein]PMID:35734936
Tnfdecreases activityISOTnf (Mus musculus)6480464CTDwithaferin A results in decreased activity of TNF proteinPMID:20438634
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDwithaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]PMID:37467946
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDwithaferin A inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; withaferin A inhibits the reaction [TNF protein promotes the reaction [ADAM17 protein results in increased cleavage of PROCR protein]]PMID:24632454 PMID:37467946
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