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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:68329
Term: syringic acid
Definition: A dimethoxybenzene that is 3,5-dimethyl ether derivative of gallic acid.
Chemical ID: MESH:C001945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDsyringic acid inhibits the reaction [Propylthiouracil results in increased expression of TNF protein]; syringic acid inhibits the reaction [Valproic Acid results in increased expression of TNF protein]PMID:34047416 PMID:35543257 PMID:37357844
Tnfdecreases secretionISOTNF (Homo sapiens)6480464CTDsyringic acid results in decreased secretion of TNF proteinPMID:33759321
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