Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3876
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tnf
Name:	tumor necrosis factor

Acc ID:	CHEBI:5855
Term:	ibuprofen
Definition:	A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID:	MESH:D007052

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnf	increases expression	EXP		6480464	CTD	Ibuprofen results in increased expression of TNF protein	PMID:21121909
Tnf	multiple interactions	EXP		6480464	CTD	Ibuprofen inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of TNF protein]	PMID:11545620 PMID:24333387 PMID:32289289
Tnf	decreases secretion	ISO	Tnf (Mus musculus)	6480464	CTD	Ibuprofen analog results in decreased secretion of TNF protein; Ibuprofen results in decreased secretion of TNF protein	PMID:17630191
Tnf	increases expression	ISO	TNF (Homo sapiens)	6480464	CTD	Ibuprofen results in increased expression of TNF protein	PMID:15263833
Tnf	multiple interactions	ISO	Tnf (Mus musculus)	6480464	CTD	Ibuprofen affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ibuprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]; Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen promotes the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; Ibuprofen promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]	PMID:10903797 PMID:15060681 PMID:16407166 PMID:9281604
Tnf	multiple interactions	ISO	TNF (Homo sapiens)	6480464	CTD	[Oxygen deficiency co-treated with Lipopolysaccharides] promotes the reaction [Ibuprofen results in increased expression of TNF protein]; GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of SELE protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Ibuprofen results in decreased activity of [TNF protein results in increased activity of CHUK protein]	PMID:10328874 PMID:10602496 PMID:11753679 PMID:14586007 PMID:15263833 PMID:15489888 PMID:16769766 PMID:9890559

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