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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:53473
Term: beryllium sulfate
Definition: A metal sulfate in which the metal is beryllium (in the +2 oxidation state) and the ratio of beryllium to sulfate is 1:1.
Chemical ID: MESH:C020711
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDberyllium sulfate results in increased expression of TNF mRNA; beryllium sulfate results in increased expression of TNF proteinPMID:10755710 PMID:10755711
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDberyllium sulfate results in increased expression of TNF proteinPMID:33197057
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDberyllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein]PMID:10755710 PMID:10755711
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