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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:5292
Term: geldanamycin
Definition: An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria.
Chemical ID: MESH:C001277
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDgeldanamycin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]PMID:12571865
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDgeldanamycin inhibits the reaction [TNF protein affects the localization of RELA protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; geldanamycin inhibits the reaction [TNF protein results in increased expression of EGFR mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of HIF1A mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; geldanamycin inhibits the reaction [TNF protein results in increased expression of RELA mRNA]PMID:11472980 PMID:37586545
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