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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionEXP 6480464CTDcypermethrin affects the expression of TNFPMID:25816392
Tnfincreases expressionEXP 6480464CTDcypermethrin results in increased expression of TNF mRNA; cypermethrin results in increased expression of TNF proteinPMID:23900960 PMID:35876585
Tnfmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [cypermethrin results in increased expression of TNF protein]; Quercetin inhibits the reaction [cypermethrin results in increased expression of TNF mRNA]; Sesame Oil affects the reaction [cypermethrin affects the expression of TNF]PMID:23900960 PMID:25816392 PMID:35876585
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDcypermethrin results in increased expression of TNF mRNAPMID:34714723
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDcypermethrin results in increased expression of TNF mRNAPMID:36063984
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDcypermethrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]PMID:29471534
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