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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:36707
Term: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine
Definition: A 2-acyl-1-alkyl-sn-glycero-3-phosphocholine where the 2-O-acyl group is specified as acetyl; a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.
Chemical ID: MESH:D010972
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfmultiple interactionsEXP 6480464CTDTNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]PMID:9065783
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDPlatelet Activating Factor results in increased expression of TNF mRNAPMID:10921504
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDPlatelet Activating Factor results in increased expression of TNF mRNAPMID:16386258
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDPlatelet Activating Factor results in increased secretion of TNF proteinPMID:16386258 PMID:32830409
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]PMID:10921504
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]PMID:32830409
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