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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:36704
Term: imiquimod
Definition: An imidazoquinoline fused [4,5-c] carrying isobutyl and amino substituents at N-1 and C-4 respectively. A prescription medication, it acts as an immune response modifier and is used to treat genital warts, superficial basal cell carcinoma, and actinic keratosis.
Chemical ID: MESH:C056493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDImiquimod results in increased expression of TNF mRNA; Imiquimod results in increased expression of TNF proteinPMID:18032482 PMID:25965695 PMID:26149470 PMID:30523158 PMID:32679548
Tnfincreases secretionISOTnf (Mus musculus)6480464CTDImiquimod results in increased secretion of TNF proteinPMID:26149470 PMID:31093508
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDCGP 57380 inhibits the reaction [Imiquimod results in increased expression of TNF protein]; hispidulin inhibits the reaction [Imiquimod results in increased expression of TNF protein]; LRCH4 protein promotes the reaction [Imiquimod results in increased expression of TNF protein]PMID:18032482 PMID:30523158 PMID:32679548
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTDCannabidiol promotes the reaction [Imiquimod results in increased secretion of TNF protein]PMID:34740670
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