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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:32888
Term: gamma-hexachlorocyclohexane
Definition: A cyclodiene organochlorine insecticide that has formula C6H6Cl6.
Chemical ID: MESH:D001556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 14995431RGDLindane increases expression of Tnf protein in serum 
Tnfincreases expressionEXP 6480464CTDHexachlorocyclohexane results in increased expression of TNF mRNA; Hexachlorocyclohexane results in increased expression of TNF proteinPMID:15025948 PMID:15135310
Tnfmultiple interactionsEXP 6480464CTD[Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]PMID:15019085 PMID:15025948
Tnfdecreases expressionISOTNF (Homo sapiens)6480464CTDHexachlorocyclohexane results in decreased expression of TNF proteinPMID:15319175
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDHexachlorocyclohexane results in increased expression of TNF proteinPMID:28177269
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TNF proteinPMID:28177269
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