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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:3093
Term: bifenthrin
Definition: A carboxylic ester obtained by formal condensation of cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylic acid and [(2-methyl-1,1'-biphenyl)-3-yl]methanol.
Chemical ID: MESH:C099952
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionEXP 6480464CTDbifenthrin results in increased expression of TNF mRNA; bifenthrin results in increased expression of TNF proteinPMID:29775722 PMID:29793499 PMID:30102949
Tnfdecreases expressionISOTnf (Mus musculus)6480464CTDbifenthrin results in decreased expression of TNF mRNAPMID:26071804 PMID:27916261 PMID:28251819 PMID:32408700
Tnfincreases expressionISOTnf (Mus musculus)6480464CTDbifenthrin results in increased expression of TNF mRNAPMID:23172818
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDbifenthrin results in increased expression of TNF proteinPMID:32061760
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDbifenthrin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]PMID:27916261
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