Gene Chemical Interaction Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	3876
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Tnf
Name:	tumor necrosis factor

Acc ID:	CHEBI:18295
Term:	histamine
Definition:	A member of the class of imidazoles that is 1H-imidazole substituted at position C-4 by a 2-aminoethyl group.
Chemical ID:	MESH:D006632

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Tnf	increases expression	EXP		6480464	CTD	Histamine results in increased expression of TNF mRNA; Histamine results in increased expression of TNF protein	PMID:36565801 PMID:38348711
Tnf	multiple interactions	EXP		6480464	CTD	TNF protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]; TNF protein inhibits the reaction [GAST protein results in increased secretion of Histamine]	PMID:11164953
Tnf	multiple interactions	ISO	Tnf (Mus musculus)	6480464	CTD	Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]	PMID:19277450
Tnf	multiple interactions	ISO	TNF (Homo sapiens)	6480464	CTD	Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]; Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Histamine promotes the reaction [TNF protein affects the localization of NFKB1 protein]; Histamine promotes the reaction [TNF protein affects the localization of RELA protein]; HRH2 protein affects the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TNF protein promotes the reaction [Histamine results in increased expression of CCL2 protein]; TNF protein promotes the reaction [Histamine results in increased expression of CXCL8 protein]; TNF protein promotes the reaction [Histamine results in increased expression of IL6 protein]	PMID:11336536 PMID:11752121 PMID:12538815 PMID:14499251

Go Back to source page

Continue to Ontology report