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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3876
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:17226
Term: rosmarinic acid
Definition: The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.
Chemical ID: MESH:C041376
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfaffects expressionEXP 6480464CTDRosmarinic Acid affects the expression of TNF proteinPMID:28744220
Tnfdecreases expressionEXP 6480464CTDRosmarinic Acid results in decreased expression of TNF mRNA; Rosmarinic Acid results in decreased expression of TNF proteinPMID:25455894 PMID:28789951
Tnfmultiple interactionsEXP 6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]; Rosmarinic Acid inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; T 0070907 inhibits the reaction [Rosmarinic Acid affects the expression of TNF protein]PMID:28744220 PMID:28815802
Tnfmultiple interactionsISOTnf (Mus musculus)6480464CTDRosmarinic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rosmarinic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]PMID:38103880
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein affects the localization of PROCR protein]; [Rosmarinic Acid results in decreased expression of ADAM17 protein] inhibits the reaction [TNF protein results in increased cleavage of and results in increased secretion of PROCR protein]PMID:23774263
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