GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Th | decreases expression | EXP | | 6480464 | CTD | Oxidopamine results in decreased expression of TH mRNA; Oxidopamine results in decreased expression of TH protein | PMID:11730701 PMID:12585172 PMID:14696016 PMID:15703272 PMID:16480889 PMID:17222394 PMID:17933546 PMID:20232137 PMID:20623773 PMID:21088802 PMID:22842585 PMID:24486959 PMID:25129099 PMID:25446857 PMID:28802652 PMID:33571554 PMID:34302886 PMID:9460767 | Th | multiple interactions | EXP | | 6480464 | CTD | 2-chloro-5-hydroxyphenylglycine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]; 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; 6-methyl-2-(phenylethynyl)pyridine affects the reaction [[GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein]; [GOPC protein affects the susceptibility to Oxidopamine] which affects the expression of TH protein; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of FOSB protein]; [TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]; [TH co-treated with GCH1] inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in increased expression of PENK mRNA]]; Drugs, Chinese Herbal inhibits the reaction [Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]]; isoquercitrin promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]; Levodopa inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]; Levodopa promotes the reaction [Oxidopamine results in decreased expression of TH mRNA]; MDL 201053 inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Resveratrol inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Rosiglitazone inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]; salvin inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; Tea inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]; Tea inhibits the reaction [Oxidopamine results in decreased expression of TH protein] | PMID:12585172 PMID:15659429 PMID:16480889 PMID:22842585 PMID:25129099 PMID:25446857 PMID:28802652 PMID:33571554 PMID:34302886 | Th | affects response to substance | ISO | TH (Homo sapiens) | 6480464 | CTD | TH protein affects the susceptibility to Oxidopamine | PMID:19815691 | Th | decreases expression | ISO | Th (Mus musculus) | 6480464 | CTD | Oxidopamine results in decreased expression of TH mRNA; Oxidopamine results in decreased expression of TH protein | PMID:15899244 PMID:16914382 PMID:17803225 PMID:23518299 PMID:29057453 | Th | multiple interactions | ISO | Th (Mus musculus) | 6480464 | CTD | LY 344864 inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; PRKN protein inhibits the reaction [Oxidopamine results in decreased expression of TH protein]; sulforaphane inhibits the reaction [Oxidopamine results in decreased expression of TH protein] | PMID:16914382 PMID:23518299 PMID:29057453 | Th | multiple interactions | ISO | TH (Homo sapiens) | 6480464 | CTD | TH protein inhibits the reaction [Oxidopamine results in increased cleavage of PARP1 protein] | PMID:19815691 | | ||||||||||||||||||||||
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