GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | decreases expression | ISO | Stat3 (Mus musculus) | 6480464 | CTD | toosendanin results in decreased expression of STAT3 mRNA | PMID:38460807 | Stat3 | decreases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | toosendanin results in decreased phosphorylation of STAT3 protein | PMID:37946196 | Stat3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | STAT3 protein inhibits the reaction [toosendanin results in decreased expression of CTSC mRNA]; STAT3 protein inhibits the reaction [toosendanin results in increased expression of GOT1 protein]; STAT3 protein inhibits the reaction [toosendanin results in increased expression of GPT protein]; STAT3 protein inhibits the reaction [toosendanin results in increased expression of SQSTM1 protein]; STAT3 protein inhibits the reaction [toosendanin results in increased lipidation of and results in increased localization of MAP1LC3B protein] | PMID:38460807 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | [IL6 protein results in increased phosphorylation of STAT3 protein] promotes the reaction [toosendanin results in decreased expression of CTSC protein]; IL6 protein inhibits the reaction [toosendanin results in decreased phosphorylation of STAT3 protein]; STAT3 protein inhibits the reaction [toosendanin results in increased expression of SQSTM1 protein]; STAT3 protein inhibits the reaction [toosendanin results in increased lipidation of and results in increased localization of MAP1LC3B protein]; STAT3 protein promotes the reaction [toosendanin results in decreased expression of CTSC protein]; stattic inhibits the reaction [[IL6 protein results in increased phosphorylation of STAT3 protein] promotes the reaction [toosendanin results in decreased expression of CTSC protein]]; toosendanin results in decreased phosphorylation of and results in decreased localization of STAT3 protein | PMID:38460807 | | ||||||||||||||||||||||
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