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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat1affects expressionISOStat1 (Mus musculus)6480464CTDchromium hexavalent ion affects the expression of STAT1 mRNAPMID:28472532
Stat1affects response to substanceISOSTAT1 (Homo sapiens)6480464CTDSTAT1 protein affects the susceptibility to chromium hexavalent ionPMID:19403854
Stat1increases activityISOSTAT1 (Homo sapiens)6480464CTD[chromium hexavalent ion results in increased activity of FYN protein] which results in increased activity of STAT1 proteinPMID:19994902
Stat1multiple interactionsISOSTAT1 (Homo sapiens)6480464CTDchromium hexavalent ion results in increased phosphorylation of and affects the localization of STAT1 protein; FYN protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of STAT1 protein]; STAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased expression of VEGFA mRNA]]; STAT1 protein affects the reaction [chromium hexavalent ion inhibits the reaction [Nickel results in increased stability of and results in increased expression of HIF1A protein]]; STAT1 protein affects the reaction [chromium hexavalent ion results in decreased expression of VEGFA mRNA]; STAT1 protein affects the reaction [chromium hexavalent ion results in increased expression of IRF7 mRNA]PMID:17078813 PMID:19403854 PMID:19994902
Stat1multiple interactionsISOStat1 (Mus musculus)6480464CTDchromium hexavalent ion results in increased phosphorylation of and results in increased activity of STAT1 proteinPMID:19994902
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