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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3752
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Spp1
Name: secreted phosphoprotein 1
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Spp1decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of SPP1PMID:21076490
Spp1decreases expressionISOSPP1 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of SPP1 mRNAPMID:21109955
Spp1increases expressionISOSpp1 (Mus musculus)6480464CTDSimvastatin results in increased expression of SPP1 proteinPMID:12914771 PMID:14601315 PMID:22058016
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