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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1increases expressionISOSp1 (Mus musculus)6480464CTDlead acetate results in increased expression of SP1 mRNA; lead acetate results in increased expression of SP1 proteinPMID:23867794 PMID:24260418
Sp1increases expressionISOSP1 (Homo sapiens)6480464CTDlead acetate results in increased expression of SP1 proteinPMID:24462621
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTDtolfenamic acid inhibits the reaction [lead acetate results in increased expression of SP1 protein]PMID:24462621
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