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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3717
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc8a1
Name: solute carrier family 8 member A1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc8a1decreases expressionISOSLC8A1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of SLC8A1 mRNAPMID:31614463
Slc8a1decreases expressionISOSlc8a1 (Mus musculus)6480464CTDEstradiol results in decreased expression of SLC8A1 mRNAPMID:30061528
Slc8a1increases expressionISOSLC8A1 (Homo sapiens)6480464CTDEstradiol results in increased expression of SLC8A1 mRNAPMID:21795739
Slc8a1increases expressionISOSlc8a1 (Mus musculus)6480464CTDEstradiol results in increased expression of SLC8A1 proteinPMID:30061528
Slc8a1multiple interactionsISOSLC8A1 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in increased expression of SLC8A1 mRNA; Progesterone inhibits the reaction [Estradiol results in increased expression of SLC8A1 mRNA]PMID:21795739 PMID:30165855
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