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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3667
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sftpd
Name: surfactant protein D
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sftpdincreases expressionEXP 6480464CTDBleomycin results in increased expression of SFTPD mRNA; Bleomycin results in increased expression of SFTPD proteinPMID:11880309 PMID:25933445
Sftpdincreases metabolic processingISOSftpd (Mus musculus)6480464CTDBleomycin results in increased metabolism of SFTPD proteinPMID:26526764
Sftpdmultiple interactionsISOSftpd (Mus musculus)6480464CTD[TNF protein affects the susceptibility to Bleomycin] which affects the expression of SFTPD protein; Bleomycin promotes the reaction [SFTPD protein binds to SFTPD protein binds to SFTPD protein]; N-((3-(aminomethyl)phenyl)methyl)ethanimidamide inhibits the reaction [Bleomycin results in increased metabolism of SFTPD protein]PMID:26526764 PMID:33647319
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