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GENE - TERM ANNOTATION REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: DOID:2945
Term: severe acute respiratory syndrome
Definition: A Coronavirus infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=SARS "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2 ISOCcl2 (Mus musculus)30309221RGDmRNA, protein: increased expression, altered expression:lung (mouse) 
Ccl2 ISOCCL2 (Homo sapiens)32716399RGDprotein:increased expression:serum (human) 
Ccl2 ISOCCL2 (Homo sapiens)34201108RGDprotein:increased expression:bronchoalveolar lavage (human) 
Ccl2severityISOCCL2 (Homo sapiens)30309218RGDprotein:increased expression:plasma (human) 
Ccl2severityISOCCL2 (Homo sapiens)30309219RGDprotein:increased expression:serum (human) 
Ccl2treatmentISOCcl2 (Mus musculus)32716426RGD  
Ccl2treatmentISOCCL2 (Homo sapiens)30309220RGD  
Ccl2 ISOCCL2 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:20484496
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