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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:9907
Term: ursodeoxycholic acid
Definition: A bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones.
Chemical ID: MESH:D014580
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDUrsodeoxycholic Acid results in increased expression of CCL2 mRNAPMID:24312631
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDUrsodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; Ursodeoxycholic Acid analog inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in increased secretion of CCL2 protein]PMID:21146893
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDUrsodeoxycholic Acid analog inhibits the reaction [TNF protein promotes the reaction [Cycloheximide results in increased expression of CCL2 mRNA]]PMID:21146893
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