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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2affects methylationISOCCL2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CCL2 promoterPMID:27901495
Ccl2decreases expressionISOCcl2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of CCL2 mRNAPMID:19770486
Ccl2decreases expressionISOCCL2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of CCL2 mRNAPMID:20064835
Ccl2increases expressionISOCcl2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CCL2 mRNAPMID:20713471
Ccl2increases expressionISOCCL2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CCL2 mRNAPMID:22316170 PMID:28351761 PMID:32234424
Ccl2multiple interactionsISOCcl2 (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to CCL2 promoter]PMID:19654925
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