Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3645
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccl2
Name: C-C motif chemokine ligand 2
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl2multiple interactionsEXP 6480464CTD[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein; SB 203580 inhibits the reaction [[Paraquat results in increased abundance of Reactive Oxygen Species] which results in increased secretion of CCL2 protein]PMID:24376630
Ccl2multiple interactionsISOCCL2 (Homo sapiens)6480464CTDRAC1 protein promotes the reaction [Reactive Oxygen Species promotes the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Reactive Oxygen Species promotes the reaction [TNF protein results in increased expression of CCL2 mRNA]PMID:14576080
Go Back to source page   Continue to Ontology report