GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ren | increases activity | EXP | | 6480464 | CTD | Enalapril results in increased activity of REN protein | PMID:6094050 | Ren | increases expression | EXP | | 6480464 | CTD | Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein | PMID:12434137 PMID:1330361 PMID:18796534 PMID:21423293 | Ren | decreases activity | ISO | REN (Homo sapiens) | 6480464 | CTD | Enalapril results in decreased activity of REN protein | PMID:18679781 | Ren | increases expression | ISO | Ren1 (Mus musculus) | 6480464 | CTD | Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein | PMID:19536436 PMID:19767874 PMID:21424707 | Ren | increases expression | ISO | REN (Homo sapiens) | 6480464 | CTD | Enalapril results in increased expression of REN protein | PMID:2994932 | Ren | increases secretion | ISO | Ren1 (Mus musculus) | 6480464 | CTD | Enalapril results in increased secretion of REN protein | PMID:19109587 PMID:19536436 | Ren | multiple interactions | ISO | Ren1 (Mus musculus) | 6480464 | CTD | [Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein] | PMID:17846348 PMID:19109587 PMID:19536436 | Ren | multiple interactions | ISO | REN (Homo sapiens) | 6480464 | CTD | [Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone] | PMID:11078175 PMID:18679781 | |
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