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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3540
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rb1
Name: RB transcriptional corepressor 1
Acc ID: CHEBI:4708
Term: doxazosin
Definition: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl group at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
Chemical ID: MESH:D017292
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rb1affects phosphorylationEXP 6480464CTDDoxazosin affects the phosphorylation of RB1 proteinPMID:18084315
Rb1decreases phosphorylationISORB1 (Homo sapiens)6480464CTDDoxazosin results in decreased phosphorylation of RB1 proteinPMID:15371785
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