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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1decreases expressionISORaf1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of RAF1 mRNAPMID:19822182
Raf1increases activityISORAF1 (Homo sapiens)6480464CTDsodium arsenite results in increased activity of RAF1 proteinPMID:9442025
Raf1increases phosphorylationISORAF1 (Homo sapiens)6480464CTDsodium arsenite results in increased phosphorylation of RAF1 proteinPMID:32890875
Raf1multiple interactionsISORAF1 (Homo sapiens)6480464CTD[sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] affects the expression of RAF1 mRNA; Lapatinib inhibits the reaction [sodium arsenite results in increased phosphorylation of RAF1 protein]PMID:23192986 PMID:32890875
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