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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1affects localizationISORaf1 (Mus musculus)6480464CTDNicotine affects the localization of RAF1 proteinPMID:15574422
Raf1increases activityISORAF1 (Homo sapiens)6480464CTDNicotine results in increased activity of RAF1 proteinPMID:17459420
Raf1multiple interactionsISORAF1 (Homo sapiens)6480464CTDAconitine analog inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; ARRB1 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Bungarotoxins inhibits the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; CHRNA7 protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]; Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]; SRC protein affects the reaction [Nicotine promotes the reaction [RB1 protein binds to RAF1 protein]]PMID:16862215
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