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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psen1
Name: presenilin 1
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psen1decreases activityISOPSEN1 (Homo sapiens)6480464CTDsulindac sulfide results in decreased activity of PSEN1 proteinPMID:17573346
Psen1decreases response to substanceISOPSEN1 (Homo sapiens)6480464CTDPSEN1 gene mutant form results in decreased susceptibility to sulindac sulfidePMID:17573346
Psen1multiple interactionsISOPSEN1 (Homo sapiens)6480464CTD[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]PMID:12805356 PMID:17573346 PMID:17962197
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