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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3371
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pparg
Name: peroxisome proliferator-activated receptor gamma
Acc ID: CHEBI:61159
Term: conjugated linoleic acid
Definition: An octadecadienoic acid having a system of two conjugated double bonds at any position.
Chemical ID: MESH:D044243
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargdecreases activityISOPPARG (Homo sapiens)6480464CTDLinoleic Acids, Conjugated results in decreased activity of PPARG proteinPMID:18776171
Ppargdecreases expressionISOPPARG (Homo sapiens)6480464CTDLinoleic Acids, Conjugated results in decreased expression of PPARG proteinPMID:16933788
Ppargincreases expressionISOPPARG (Homo sapiens)6480464CTDLinoleic Acids, Conjugated results in increased expression of PPARG mRNA; Linoleic Acids, Conjugated results in increased expression of PPARG proteinPMID:15961301
Ppargincreases expressionISOPparg (Mus musculus)6480464CTDLinoleic Acids, Conjugated results in increased expression of PPARG mRNAPMID:17322064
Ppargmultiple interactionsISOPPARG (Homo sapiens)6480464CTDLinoleic Acids, Conjugated results in increased phosphorylation of and results in increased activity of PPARG protein; resveratrol inhibits the reaction [Linoleic Acids, Conjugated results in decreased activity of PPARG protein]; resveratrol inhibits the reaction [Linoleic Acids, Conjugated results in increased phosphorylation of and results in increased activity of PPARG protein]PMID:18776171
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