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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3369
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparadecreases expressionISOPpara (Mus musculus)6480464CTDLithocholic Acid results in decreased expression of PPARA mRNAPMID:20359477
Pparamultiple interactionsISOPpara (Mus musculus)6480464CTD[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of PPARA mRNAPMID:20359477
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTD[PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]PMID:18648741
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