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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3249
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpine1
Name: serpin family E member 1
Acc ID: CHEBI:27641
Term: cycloheximide
Definition: A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.
Chemical ID: MESH:D003513
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Serpine1multiple interactionsEXP 6480464CTDCycloheximide inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; Cycloheximide promotes the reaction [FGF2 protein results in increased expression of SERPINE1 mRNA]PMID:9798919
Serpine1multiple interactionsISOSerpine1 (Mus musculus)6480464CTDCycloheximide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]PMID:12111005
Serpine1multiple interactionsISOSERPINE1 (Homo sapiens)6480464CTDCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 mRNA]PMID:11007951
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